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Vitamin B12 deficiency is Symptoms of B12 deficiency include: rapid breathing shortness of breath headaches palpitations or fast heart rate indigestion, diarrhea, or loss of appetite blurry vision weakness or tiredness mouth ulcers or irritation cognitive changes, such as difficulty with memory, judgment, or understanding infertility Contact your doctor to discuss injections or supplements if you experience any conditions or risk factors related to vitamin B12 deficiency