In human gingival mesenchymal stem cells, Epitalon regulates gene expression and protein synthesis: it preferentially binds to histones H1/6 and H1/3 at sites that interact with DNA, thus suggesting that binding to histones may be an additional mechanism for enhancing the expression of genes that regulate neuronal differentiation and protein synthesis [10]
For randomised clinical trials, the Jadad scale (Jadad et al., 1996), as used to assign a quality score ranging from 0 to 5, based on randomisation, blinding, and withdrawal reporting
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