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It has a lot of carotenoids, like lycopene, - and -carotene, and zeaxanthin, along with the water-soluble apocarotenoid crocetin and its glycosyl esters, which are called crocin

The primary endpoint, major adverse cardiovascular events (MACE), was the time to first occurrence of a three-part composite outcome which included CV death, non-fatal myocardial infarction (MI) and non-fatal stroke

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"Clinical activity of folinic acid in patients with chronic fatigue syndrome"

Both of these were taken from pure fat burners to supplements that were more like "light energy supplements", and the removal of higenamine was definitely part of those reformulations