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doi:10.1016/j.npep.2004.05.009 152

Pregnancy and Lactation: Recognizing the lack of comprehensive studies on semaglutides effects during pregnancy and breastfeeding, we advise against its use to safeguard maternal and infant health

Specific benefits for people with high blood pressure include: Weight reduction : Weight loss varies by agent and dosemore substantial with higher doses of semaglutide (Wegovy) for obesity management, and more modest with standard diabetes doses of GLP-1 agonists Reduced arterial stiffness : Some studies suggest GLP-1 agonists may improve vascular function Kidney effects : Some GLP-1 agonists have shown benefits in reducing albuminuria and slowing kidney disease progression, though SGLT2 inhibitors are generally preferred for kidney protection in diabetes [10] [19] Reduced cardiovascular events : The overall reduction in heart attacks and strokes benefits people with hypertension However, it is important to understand the potential risks and side effects

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Variants in GLP1R, GIPR, and metabolic genes may influence how your body processes GLP-1 agonists for weight or glucose management, but do not predict fibromyalgia-specific outcomes