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pH 7.39, osmolarity 320 mOsm) with 10 nM ghrelin or 10 nM GLP-1

Human studies showed a protective role of GLP-1R in the progression of coronary atherosclerosis through several pathways associated not only with metabolism but also with the polarization of macrophages

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Several GLP-1 and dual GIP/GLP-1 receptor agonists have been developed to harness these pharmacological effects in the treatment of type 2 diabetes, with some demonstrating robust effectiveness in weight management and prevention of cardiovascular diseases