While these results suggest that lysosomal cathepsins do not appear to play a role in APAP-induced hepatotoxicity, lysosomes are an important source of iron, a catalyst known to stimulate ROS generation
With clinically meaningful weight loss and cardiovascular outcomes in patients with type 2 diabetes, GLP-1RAs were further assessed in patients with overweight or obesity without type 2 diabetes in the 2021 STEP-1 trial and 2022 SURMOUNT-1 trial
doi: 10.1210/jc.2003-030242 69 MargolisKLBondsDERodaboughRJTinkerLPhillipsLSAllenCet al
There were no treatment discontinuations related to the study drug
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