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Conjugation Glutathione-S-transferases attach glutathione to electrophilic drugs, chemical metabolites and other reactive compounds, preparing them for further processing and excretion

The majority of published in vitro studies use concentrations ranging from 0.1 to 10 micromolar, with 1 micromolar being the most widely referenced benchmark

Exposure to 40C or above can destroy the peptide within hours

The molecular mechanisms of SNRIs can be summarized as follows: First, SNRIs inhibit the norepinephrine transporter (NET), which prevents the reuptake of NE into presynaptic neurons, leading to an increased concentration of NE in the synaptic cleft

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