PT-141: nausea, flushing, mild headache
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Apart from ASCT2 multiple important transporters exist: LAT1 (L-type amino acid transporter 1): The LAT1 transporter operates as a neutral amino acid transporter enabling glutamine passage through the plasma membrane by exchanging it with other amino acids including leucine
Astrocyte dysfunction, beyond disrupting water and potassium homeostasis through altered AQP4 and Kir4.1 expression, amplifies neuroinflammation around degenerating motor neurons, exacerbating their deterioration