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400,000 B16-F10 murine melanoma cells were injected into the tail vein of C57BL/6 mice

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While the ipsilateral precursory lesion could be explained by an early focal invasion by immune cells that remain dormant for years, the contralateral mirror lesions are harder to ascribe to such a mechanism

Conicts of Interest: Rosario Russo was employed by the company Giellepi S.p.A

Furthermore, ALA directly increases the intracellular synthesis of glutathione, the body's master antioxidant, by enhancing the cellular uptake of its precursor amino acid, cysteine