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- Most evidence comes from animal studies - Human data is extremely limited - No FDA approval for orthopedic use - Clinical benefit in musculoskeletal conditions remains unproven While the biology is interesting, potential does not equal proven clinical outcomes

This is because the improvement of intestinal microecology helps to reduce the number of ammonia-producing bacteria in the intestines, lower ammonia production and absorption, and thereby help improve the neurocognitive dysfunction of patients with hepatic encephalopathy

However, topical administration of BPC 157 led to a significant increase in tensile breaking force

coli Nissle 1917 in polarized human colonic cells against Campylobacter jejuni infection

Healthletic's BPC-157 is available for purchase without a prescription and is shipped within the USA