The differential diagnosis of conjunctival lesions include complexion-associated melanosis (CAM), nevus, primary acquired melanosis (PAM), and melanoma.1 Most conjunctival melanomas arise from precursor lesions, with approximately 75% arising from PAM with atypia and less than 10% from nevi.2 De novo cases account for 15%25% of occurrences.2 The incidence of conjunctival melanoma is increasing, with a risk of death of around 30%.3 Complexion-associated melanosis lesions pose no malignancy risk, are often bilateral (though are sometimes asymmetric) and predominantly located perilimbally, and are more common in individuals with darker-pigmented skin (Figure 1).1 In contrast, PAM lesions are typically unilateral, flat, variably pigmented, with potential change in size and shape over time, and, most importantly, have malignant potential (Figure 3).4 Primary acquired melanosis lesions are, by definition, acquired and may present as new pigmentation on the ocular surface

MD Tips for Better Results Ozempic and Wegovy, both semaglutide medications for weight loss, can be injected under the skin in the abdomen, thigh, or upper arm, with rotating injection sites recommended to avoid side effects like redness and bruising
Some users prefer morning injection to support daytime activity and recovery, while others favor evening administration to align with natural growth hormone release during sleep
Conflict of Interest: David Buchebner, Elin Skoglund, Kristofer Rigner are all employees of Yazen Health
So far so good Unpleasant smell/taste