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veterans with type 2 diabetes found that GLP-1s were associated with lower risk of developing substance use disorders (SUDs) involving alcohol, cannabis, cocaine, nicotine or opioids

They are hormone-like drugs that help your own pancreas release insulin in a more natural, glucose-dependent way and also reduce excess sugar from the liver and help you feel full sooner

206,210 Additionally, activation of GLP-1R has been demonstrated to promote cell survival during glucotoxic and lipotoxic conditions, excessive nitric oxide levels, Ca 2+ depletion, oxidative stress, and cytokine-induced endoplasmic reticulum stress in primary beta-cells and cell lines

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Efficacy and safety of exenatide once weekly versus sitagliptin or pioglitazone as an adjunct to metformin for treatment of type 2 diabetes (DURATION-2): a randomised trial