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Safety and tolerability profiles may differ once data from long-term, head-to-head or large comparative studies become available

Montesinos MC, Desai D et al (2003): Adenosine A2A or A3 receptors are required for inhibition of inflammation by methotrexate and its analog MX-68

Because B12 is so closely linked to energy production and normal bodily function, it has become a common supplement in wellness and weight-loss settings

notably, the protocol did not include guidance on caloric restriction

Initially in a dehydrated state and once in the respiratory tract, they rapidly hydrate causing swelling and expansion due to their size, sugar content, and polymerisation into long chains [37,38,39]