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Nonetheless, this work has identified novel findings that support future studies to determine whether microbiome changes are contingent upon the combination of both NNMTi and LD switch and mediated through direct NNMTi-driven mechanisms or through indirect mechanisms such as weight or fat loss 8,13

PMID 20585951

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The medication is commonly used alongside metformin, with the combination often providing complementary mechanisms of action for improved glycemic control