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The GLP-1 receptor (GLP-1R) is a G-protein-coupled receptor widely expressed in various tissues, including the pancreas, brain, and gastrointestinal tract

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But when glutamate activity becomes excessive, it can contribute to mental overstimulation, poor concentration, sensory overload, and the familiar wired-but-tired feeling

By contrast, CIBB treatment in the CI-M group significantly reduced the percentage of M1 macrophages (31.81% in the CI-M group) and increased the percentage of M2 macrophages (26.18% in the CI-M group) close to that in the control group