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Investigations of biomarkers of DHD and their applications have significantly progressed
In the Phase IV study, semaglutide will be evaluated for its effects on improving depressive symptoms over 26 weeks in patients with major depressive disorder who also have overweight or obesity (Vinberg, 2026, ID NCT07136714)
The observed protective effects are mediated through multiple molecular mechanisms, including enhanced metabolic regulation, direct anti-proliferative actions, and augmented immune surveillance [16, 17]
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