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In patients with AS, the expression of miR-345-3p is upregulated while that of miR-2412 is downregulated in seminal EVs, suggesting that these may influence downstream related proteins through regulation of target genes, thereby affecting sperm motility (Taravat et al., 2024)

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IGF-1 LR3 is investigated in preclinical research for IGF-1R signaling, PI3K/Akt/mTOR pathway activation, skeletal muscle protein synthesis, and metabolic pathway research