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Linking the olfactory system and the detoxification system, animal studies show that GST (glutathione s-transferase) and CYP450 enzymes actually participate in odorant clearance and the olfactory process

How things go bad As we get older, our brain chemistry and energy metabolism changes.[vii] Nerve growth factor in the brain declines Acetyl-L-Carnitine levels decline Acetylcholine levels decline Mitochondria loses efficiency All of these age-related changes are contributing factors to cognitive impairment and the neurodegenerative diseases of aging, including Alzheimers and dementia

This assumption is supported by the finding that only the overexpression of GCL, and not of GS, results in increased GSH levels (6)

The effects on EPSC frequency were associated with respective increases or decreases in intracellular glutamate