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Regarding the complex neurobiology of NO in depression, studies reveal that maintaining NO within its physiological range is the most probable therapeutic strategy (10)

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Hippo signaling regulates YAP primarily through large tumor suppressor kinases 1 and 2 (LATS 1/2), which are activated through phosphorylation by mammalian sterile 20-like protein kinases 1/2 (MST1/2)