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Detoxification and breaking down substances: Methylation is essential in the nervous system, in the production and breakdown of neurotransmitters, and in detoxifying some specific environmental toxicants such as arsenic

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We think this could lead to new interventions, such as reducing the glutathione overload through synthesis inhibitors or compounds that can dissipate it. The findings also have implications for potential therapies for lung cancers related to mutations in the KEAP1 gene

Then, a refined derivative, PT-141, which isolated the central MC4R pathway and ultimately achieved pharmaceutical approval

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