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Despite the potential clinical benefits of NAC+GLY for slowing and perhaps even reversing T2D progression, there is a practical issue in its clinical utilization, i.e., it is not entirely clear if NAC is a drug or dietary supplement from a regulatory point of view

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After undergoing TCA cycle metabolism to malate, mitochondrial malate is exported to the cytosol, where malic enzyme (ME) converts it to pyruvate [10]

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