Detoxifies electrophilic agents Eliminates reactive oxygen species (ROS) and reactive nitrogen species (RNS) Maintains the essential thiol redox state of proteins Maintains metal ion homeostasis and regulates key cellular processes -L-Glutamyl-L-cysteinyl-glycine A tripeptide composed of glutamic acid, cysteine, and glycine The most abundant non-protein thiol compound in various cells
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Protein glutathiolation by nitric oxide: an intracellular mechanism regulating redox protein modification
Reference: Neelakantan H, Vance V, Wetzel MD, Wang HY, McHardy SF, Finnerty CC, Hommel JD, Watowich SJ (2018)
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