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Brain-gut and appetite regulating hormones in the control of gastric secretion and mucosal protection

In fact, growth retardation is common in these patients, who usually present with short stature and lower body mass index (134, 135)

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Concurrently, insulin resistance drives hepatic de novo lipogenesis through activation of sterol regulatory element-binding protein-1c (SREBP-1c) and carbohydrate-responsive element-binding protein (ChREBP), leading to triglyceride accumulation in hepatocytes

The pituitary responds to two different signals