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Experimental post-infarction models have demonstrated that both cardiac and pulmonary vascular endothelial dysfunction contribute to heart failure development

At higher doses (above 3 grams per day), some individuals may experience mild gastrointestinal discomfort

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Signals of thiomethyl metabolites were always low for blood samples collected less than 6h apart, showing that elimination of NAPQI (either after conjugation to glutathione or the antidote) is also subject to a delay in case of acute intoxication