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Distribution of the histaminergic neuron system in the central nervous system of rats

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Additional MS and MS/MS spectra are available in Figures 4B,C and Figure S1

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Cannabinoid receptor 1 (CB1R) is expressed in presynaptic and postsynaptic neuronal sites in the lateral habenula, where they modulate behavioral responses to stress exposure, such that CB1R blockade reduced anxiety-like behaviors [50] and also in GABAergic cells in the ventral tegmental area (VTA) and their stimulation increases firing of dopamine neurons, which modulate reward [51]