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Characterization of a glutathione metabolic mutant of Mycobacterium tuberculosis and its resistance to glutathione and nitrosoglutathione
In some embodiments, the otic formulation or composition comprises between about 0.001% to about 5% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof
In the human liver microsomes, Deg-AZM, M1-2 (hydroxylation of Deg-AZM), and M2 (demethylation of Deg-AZM) were the main forms of the drug, accounting for 34.4%, 30.0%, and 17.1% of the total related substances, respectively
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