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Uche-Anya E et al

59 Modulation of chromatin looping by the co-activators Prior to the emergence of topological associating domains (TADs), the precise control of transcriptional activation relies on the interaction between remote cis-regulatory modules (e.g., enhancers, and the promoter

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This bidirectional behavior highlights a critical context dependence in antioxidant biology, where the same metabolite may either suppress or amplify ferroptotic stress depending on iron availability and intracellular redox flux