Semaglutide The active ingredient in Wegovy and Ozempic The mean change in body weight from baseline to week 68 was -14.9% in the semaglutide group, as compared with -2.4% with placebo. STEP 1, Wilding JPH et al., NEJM 2021;384:989-1002 Tirzepatide The active ingredient in Mounjaro and Zepbound At 72 weeks, the mean percentage change in weight was -20.9% with 15 mg of tirzepatide, as compared with -3.1% with placebo. SURMOUNT-1, Jastreboff AM et al., NEJM 2022;387:205-216 These figures are trial averages for the branded formulations
Semaglutide Names Semaglutide has two brand names: Wegovy used for weight loss Ozempic used for diabetes Tirzepatide Names Tirzepatide also has two brand names: Zepbound used for weight loss Mounjaro used for diabetes Both medicines were first made to help people with diabetes
However, changes in appetite and weight loss can influence mood, which might indirectly affect neurotransmitter activity, including serotonin
I want to run with them and play with them
FDAs determination to remove semaglutide from the drug shortage list is not surprising
