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Hyperexcitability may represent a consequence of genetic functional variants in mtDNA, ion channel and/or neurotransmitter receptor structure, or may result from aberrant neural circuits development

By lowering the inflammation burden, the MD may help improve tolerability and enhance semaglutides efficacy in improving glycaemic and metabolic outcomes, especially in patients with high inflammatory burden, metabolic syndrome, or comorbid inflammatory conditions [125, 126]

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Digoxin is a cardiac glycoside that, due to its senolytic action, possesses limited anticancer effects [140]

GLP-1s can be taken alone or with other medications, including insulin, metformin, and SGLT-2 inhibitors