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3.2 STING STING and autophagy are connected on four levels: (i) STING facilitates non-canonical induction of autophagy, (ii) microautophagy and selective macroautophagy can induce STING degradation, (iii) ULK1 negatively regulates STING-IRF3 signaling by phosphorylating STING, and (iv) non-canonical RAB22-mediated autophagy can promote intercellular spreading of activated STING ( Figure 4 )