13 In addition to filing and being granted patents for the compound semaglutide, Novo Nordisk has filed and been granted patents covering derivative compounds of semaglutide
The NY times just highlighted this in the magazine section this week
Of note is that the observed median time to onset of the psychiatric AEs in our analysis of the FAERS data aligned with common gastrointestinal AEs such as nausea and vomiting, which were the most frequently reported within the first 30 days of GLP-1 RA treatment ( In this extensive pharmacovigilance study, we observed a significant association between GLP-1 RAs and eight distinct categories of psychiatric AEs, namely, nervousness, stress, eating disorder, fear of injection, sleep disorder due to general medical conditioninsomnia type, binge eating, fear of eating, and self-induced vomiting

2 In addition to lifestyle modifications (diet and exercise), many pharmacologic strategies have been proposed to counter iatrogenic weight gain, including appetite suppressants (eg, pro-dopaminergic agents such as phentermine, stimulants, and amantadine), pro-anorectant anticonvulsants (eg, topiramate or zonisamide), opioid receptor antagonists (eg, olanzapine/samidorphan or naltrexone) and oral hypoglycemics such as metformin
Do androgens modulate the pathophysiological pathways of inflammation