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Phase 2 trial (Lancet 2021) tested cagrilintide 0.3 mg through 4.5 mg/week as monotherapy and reported a clear dose-response, with 10.8% mean weight loss at 4.5 mg/week at 26 weeks

The opioid antagonist naloxone appears to block some of DSIPs effects, so combining these would likely negate DSIPs benefits

35 Although beyond the scope of this manuscript, analyzing predictors of response to 1 year and beyond could be an avenue for future research and help inform clinical decision-making

What they found: Cells exposed to BPC-157 began to form capillary tubules, small prototypes of new vessels

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