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Sources reviewed include the official Vital Blood product website (thevitalblood.com), the brand's Terms of Service and published FAQ, the brand's Supplement Facts panel as documented in official product materials, and peer-reviewed literature on L-Arginine, L-Citrulline, and blood pressure from PubMed and PMC (National Library of Medicine), including a 2019 systematic review in Nutrients on oral L-Arginine and L-Citrulline supplementation, a 2022 systematic review and meta-analysis in Advances in Nutrition, and a 2024 assessment of registered clinical trial designs published in Pharmaceuticals

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GLP-1R mRNA and GLP-1 immunoreactivity was detected in the VTA and NAc, as well as other reward associated areas including lateral hypothalamus, lateral habenula, hippocampus, and substantia nigra (Merchenthaler et al., Afferent and efferent innervation of the hindbrain GLP-1-producing neurons Unlike many of its gut or fat hormone counterparts (ghrelin or leptin) for which there is little evidence of central production, GLP-1 can be made in the brain