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Vegans and "patients with diseases like Crohn's and colitis as well as people with pernicious anemia are also particularly vulnerable to deficiency," added Silverstein

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A meta-analysis of 28 studies with 74,660 patients who had bioprosthetic valves and atrial fibrillation showed that DOACs were more effective in reducing the risks of bleeding, strokes, systemic embolism, and intracranial bleeding when compared to warfarin