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GLP-1 agonists act on receptors in the hypothalamus to reduce appetite and increase satiety
The CAS is composed of ACO2, IDH2, SLC25A11 (2-oxoglutarate carrier), IDH1, cytoplasmic aconitase 1 (ACO1), and SLC25A1 (Jamerson and Bradshaw, 2024)
Details of the registries and codes used for cancer diagnoses, drug exposure and covariates are provided in electronic supplementary material (ESM) Methods and ESM Tables 13
Weight changes may begin in a few weeks, while more significant changes may take time and consistency
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