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LY4101174 and LY4052031 are two next-generation Nectin-4-targeting ADCs that have demonstrated robust antitumor activity across a range of Nectin-4 expression levels and in a Nectin-4-MMAE ADC-resistant tumor model in the preclinical setting 185,186

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Additionally, CD117 is expressed at high levels in OCSCs and plays a role in tumor initiation and resistance to cisplatin/paclitaxel by activating the Wnt/-catenin-ABCG 2 pathway (76)

it includes key cofactors that boost its production and effectiveness: N-Acetyl Cysteine (NAC): A precursor to glutathione, boosting its natural production