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It has no established GABAergic activity, no demonstrated receptor, no reliable acute sedative effect, and no dose at which sedation predictably occurs
Common side effects include nausea, gastrointestinal disturbance, and injection site reactions
In a trial of people who had reached the full dose of semaglutide, those who switched to a placebo regained weight over the following months, while those who continued the treatment kept losing weight
Cruz-Jentoft AJ, et al
Importantly, a WM-CR group for RETA could not be established because of the extreme weight loss observed with RETA which could not be implemented through CR alone
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