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However, emerging evidence suggests that stopping therapy often leads to weight regain, reinforcing the concept of obesity as a chronic condition requiring ongoing pharmacologic support

Research showed that glucagon co-agonism increased hepatic fat oxidation and thermogenesis, providing an additional fat-loss mechanism distinct from appetite suppression alone

Thats exactly the tone of the most voted positive review for tirzepatide: a clear, lived-story of metabolic change

[PubMed: 25411237] 14