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These modifications significantly extend the peptides half-life and reduce binding affinity to IGF-binding proteins compared to native IGF-1

These injections last just under a week, so it is recommended to receive the injections twice a week, and include a Vitamin B12 shot for maximum benefit

GLP-1RAs in patients with psoriasis

Vitamin C:Vitamin C is also a strong anti-oxidant and anti-pigmentation agent

Systemic Therapies: Reserved for Refractory Cases For patients with severe or refractory CHE, systemic therapies such as oral retinoids (e.g., alitretinoin) and immunosuppressants (e.g., cyclosporine, methotrexate) may be considered [91]