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Metformin frequently causes gastrointestinal side effects including diarrhea, nausea, abdominal discomfort, and metallic taste, affecting approximately 20-30% of patients, particularly during initiation
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The study involved 132 randomly assigned participants to receive either semaglutide or a placebo for 26 weeks
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While both can be administered concurrently, the pharmacological rationale is weak youre layering pulsatile GH stimulation on top of sustained elevation, which defeats the purpose of preserving natural pulse dynamics
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