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investigated the traits of cultured human retinal pigment epithelium (ARPE-19) cells exposed to NaIO 3 and observed that the process of cell death was concomitant with the deficiency of reduced thiol groups (particularly GSH and cysteine) as well as the amplified release of labile iron, which replicated the critical features of ferroptosis ( 3 , which was exacerbated by silencing FSP1 and GPX4 ( 3 , was recently viewed as an upstream regulatory molecule of RPE ferroptosis ( 3 -induced ROS caused the damage to RPE cells by ferroptosis