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doi: 10.4049/jimmunol.162.7.3749 215 FujimotoYShimoyamaASudaYFukaseK

Retatrutide is investigational and not approved for human use

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Recent studies have documented that GLP-1R engagement in the portal circulation is reduced under high-fat dietfeeding conditions (68), suggesting together with our data that multiple mechanisms converge to control GLP-1 action in the hepatic portal circulation, which may contribute to glucose dysregulation in mice upon high-fat feeding

Mechanistic insight into drivers of the NRF2 dependency remains poorly understood