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Ipamorelin stands alone in the GHRP class for producing GH elevation without meaningful effects on the ACTH-cortisol axis

Preclinical data suggest GIP receptor engagement modulates lipid partitioning pathways and may act synergistically with GLP-1 receptor signalling in energy-balance models

The paper suggests initiating therapy at roughly 1025% of standard starting dose for type 2 diabetes or obesity, which for tirzepatide (approved starting dose 2.5 mg) would be roughly 250625 g, or 0.25 0.625 mg

doi: 10.21037/tau-22-663 119 ChenLWangCWangYHongTZhangGCuiX

Constipation is the most statistically common complaint at this dose, driven by dramatically slowed gastric motility