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Mecasermin loses approved indication once growth plates close
Elevated B12 is more commonly caused by myeloproliferative disorders, certain cancers, renal failure, or excessive supplementation
C domains are most commonly encoded in the same coding DNA sequence (CDS) as their acceptor molecules, upstream of the corresponding A domain and there are only very few examples were a C domain is located in the C terminal proximitiy of the preceding CDS in NRPS 32,33,34
Both are being researched for their ability to release growth hormone but they work differently and have different effects in research models
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