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While multi-agonism with incretin hormones and glucagon has demonstrated great therapeutic potential, the conceptual approach of polypharmacology has also been extended to other hormone combinations

The incretin glucagon-like peptide-1 (GLP-1), released from the gut during food intake, amplifies glucose-stimulated insulin release by binding to and activating its cognate G protein-coupled receptor (GPCR), the GLP-1 receptor (GLP-1R), triggering cAMP generation and downstream Protein Kinase A (PKA) and Exchange Protein Activated by cyclic AMP 2 (Epac2) signalling 4 , a process that has been exploited to develop pharmacological GLP-1R agonists (GLP-1RAs) as T2D therapies

What should I do if I already bought the patch

Increase when you and your healthcare provider agree that incremental clinical benefit justifies the incremental side effect burden of a higher dose

It is a suitable option when diet and exercise alone are not enough to control blood sugar