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Therefore, as expected we found increased mRNA expression of Gsr and other NRF2-regulated genes ( Gclm , Nqo1 , Srxn1 and Hmox1 ) (Fig 2A), as well as NRF2 and GSR protein abundance (Fig 2B) in LPS-stimulated RAW264.7 Ms with accumulated oxLDL

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In addition, postmenopausal women not on hormone therapy had improvements in fasting glucose ( P = .001), HbA1c ( P = .0002) and systolic BP ( P = .008) from baseline to 12 months

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