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Likewise, another dualAG named cotadutide (MEDI0382) was more effective than obeticholic acid in improving liver metabolism and ameliorating MASH and fibrosis in C57BL/6J or ob/ob mice on a high trans-fat/fructose/cholesterol diet 14 , as well as decreased liver inflammation and apoptosis in adipocytes 15

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According to the Cleland nomenclature the reaction should follow a uni-uni-bi-uni ping-pong mechanism 8,59 , although detailed kinetic studies to confirm the mechanism for EcGrx1 or the F