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doi: 10.1111/1753-0407.12198 172 RosenstockJSorliCHTrautmannMEMoralesCWendischUDaileyGet al

Place under tongue and hold for 2 minutes before swallowing

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GHK-Cu's copper coordination complex can undergo structural rearrangement during freezing as ice crystal formation concentrates solutes and shifts local pH, potentially causing copper dissociation from the peptide and subsequent loss of biological activity upon thawing