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The copper complexes of the peptides Gly-Gly-His (GGH), Gly-His-Lys (GHK) reduced TNF-alpha induced secretion of proinflammatory cytokine IL-6, in normal human dermal fibroblasts, while saccharomyces/copper ferment (OligolidesA Copper) had no effect

The resulting lipid peroxide radical (LOO ) can then propagate the radical reaction by abstracting hydrogens from neighboring phospholipids or can react with itself to create a large number of secondary peroxidation products (Figure 7)

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Abbreviations ARC, arcuate nucleus