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DA-JC1 was more effective against neuronal degeneration than Val(8)-GLP-1, with higher scores of neurological function and level of Bcl-2, but lower cerebral infarction, expression of iNOS and Bax, and percent of TUNEL-positive neurons in the group treated with DA

Heat map for top 5 genes per enriched pathway in ( b ) Gipr Syn / vehicle-treated and Gipr fl/fl mGIPR-Ab/P1-treated mice, and ( d ) Glp1r Wnt1 / vehicle-treated and Glp1r fl/fl mGIPR-Ab/P1-treated mice

Determining the best weight loss medication requires looking at more than just the headline percentage

We spoke with Seth Kipnis, M.D., a board-certified general surgeon and Medical Director of Bariatric and Robotic Surgery at Jersey Shore University Medical Center, and Ritu Anand, M.D., a board-certified endocrinologist at the Center for Weight Loss at JFK University Medical Center, to explain how bariatric surgery and GLP-1s work, who theyre best for, and what to expect so you can discuss the next right step with your care team

Unlike traditional weight loss drugs that mainly suppress appetite, retatrutide targets several pathways simultaneously